Break Points Not Hit in VS 2008

Hi.

I have an ASP.NET application written in C# running under IIS 7. I have
tried to debug it using VS 2008 w/ SP1 first under Vista Home Premium,
then under XP Pro. Each time, the first break point gets hit, but no
other break points get hit after that.

The break points are there. I do not get a "break point will not be
executed" message. The break points are just not hit.

I never had this problem with VS 2005. Does anybody have any ideas
about what might be wrong?

Thanks for the bandwidth.

- Doug